Van de Ven Double Ends The Toffees' Run at Brand New Home Ground
Micky van de Ven became the initial defender to score twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads into the net two times in opening period
Everton's Jake O'Brien has equalizer disallowed after VAR review
Pape Matar Sarr nets final goal in dying moments
This loss is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs extended their winning streak on the road in the Premier League and handed the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the end of the previous campaign.
But Spurs captain the Dutchman pounced on two occasions from corners in the first half to place their impressive record at risk, and they were failed to turn it around before the midfielder - assisted by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.
Jake O'Brien believed he had levelled the scores a short while after the defender's first goal, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, failed to convert a number of chances, while the Italian goalkeeper made a succession of fine stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the goal on the screen and the official decided that Jack Grealish and the attacker were in an illegal position and had interfered with the Spurs keeper.
The win elevates Thomas Frank's team into third place in the division, five points off local foes and table-toppers Arsenal.
Everton remain in 14th position and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven excels in duties at each end of pitch
After a uninspiring midweek performance in the Champions League against the French side, where they mustered a mere two shots on target, the manager chose the French striker in attack instead of ex-Everton forward Richarlison.
The summer signing was failed to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the end.
Defender the Dutchman converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked the defender to score.
And the captain - stepping up as skipper in the Argentine's unavailability - added his second in first-half stoppage time as he rose above Jordan Pickford to nod in.
Van de Ven was just as impressive in defence, combining well with Kevin Danso as the duo handled superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees lacking finishing touch
The club's new home had been a fortress, but it seems the freshness may have faded somewhat and fans headed to the gates after Sarr's final goal for Spurs.
The break in Everton's winning streak at home will not be a major worry for David Moyes, but their attacking woes are.
The forward and Thierno Barry - the Toffees' two recognised strikers - had netted only one league goal between them before Sunday's match.
And they were unable to add to that poor record on a wet and gloomy night on in Liverpool.
Beto's form was epitomized when he chose to overhead kick a golden opportunity from close range, even with having space and time to reposition for a simpler attempt that would have tested the keeper.
The substitute, too, failed to influence the game after coming on for Beto in the 65th minute.
It was not for a shortage of chance. Most of Everton's attacks came through Grealish and Ndiaye, who relentlessly whipped threatening crosses into the Spurs box.
Upcoming fixtures for these two sides?
Everton: Moyes' men travel to Sunderland in the top flight on early November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on late October for their next round League Cup match against Newcastle.